Twenty-six years ago today, on March 25, 1999 (February 8, 1999 lunar calendar), our country's first transgenic cow was born. Genetic medicine experts Zeng Yitao (left) and Huang Shuframe. On March 25, 1999, the reporter learned from the Chinese Academy of Engineering's seminar on transgenic animals and the pharmaceutical industry that the Shanghai Institute of Medical Genetics successfully bred transgenic sheep in 1998, and in early 1999 successfully bred our country's first transgenic test-tube cattle. The transgenic cow was a bull named "Tutao". It was born on February 19 at Fengxin Animal Testing Site, Fengxian County, Shanghai, weighing 38 kg at birth. After DNA (deoxyribonucleic acid) analysis, it carried the human serum albumin gene. Professor Zeng Yitao, academician of the Chinese Academy of Engineering and head of the research group, introduced that after the bull was mature and bred, its "daughter" gave birth to a calf, which was expected to secrete milk containing human serum albumin, which marked another new step in the research of transgenic animals in our country. In 1998, Professor Huang Shuframe and Professor Zeng Yitao of the Shanghai Institute of Medical Genetics led the research group to create a new technical route for transgenic sheep integrating embryo transfer, which greatly improved the success rate of transgenic sheep. On the basis of the success of transgenic sheep, on May 27, 1998, the research group applied the new technical route created to conduct transgenic test-tube cattle tests. Among the eight tested cattle, three were pregnant, two of which miscarried in the second trimester, and the other gave birth to a transgenic test-tube bull with human serum albumin gene integration at full term. This result confirms that the new technology route of transgenic sheep established by Shanghai Medical Genetics Institute is also suitable for the development of transgenic animals for large domestic animals. Professor Huang Shuframe of the research group analyzed that due to the long reproductive cycle of cattle and the high investment cost, transgenic cattle are more difficult. However, compared with transgenic sheep, a cow can produce up to 10,000 kilograms of milk per year, which is more than 20 times higher than that of goats. Therefore, transgenic cattle are more suitable for producing some precious medicines that require large quantities. Human serum albumin is currently a drug that is in high demand and in short supply in China. If this drug can be produced from milk, this situation will be greatly changed. The first transgenic test-tube cow in our country is "surging"