On January 14,2019 (December 9, 2018), the world's first use of "longevity medicine" on humans. January 14,2019, Today in History, Recently, Lancet published for the first time the report of treating 14 elderly people with mild to moderate idiopathic pulmonary fibrosis with anti-aging drug Senolytics, which is also the first human trial result of this kind of drug in the world! Each participant took two drugs, dasatinib and quercetin, three days a week for three weeks, which significantly improved mobility and reduced weakness without affecting other physiological indicators such as grip strength and lung function. The clinical effectiveness of "longevity drugs" will help humans continue to extend their lives, perhaps in the future humans will not only live to 120 years old, but also age qualitatively. So can "longevity medicine" make "longevity" a reality? Today, let's give you a detailed science popularization! How does aging happen? The aging of the human body is caused by the aging of cells. When senescent cells stop dividing and continue to accumulate, especially in the aging biological immune system, senescent cells cannot be eliminated in time and gradually exceed non-senescent cells in number. The secreted protein damages the surrounding cell nuclear tissue, and the tissue appears "old state", leading to health conditions. Cell aging is usually caused by persistent DNA damage caused by various internal and external stimuli such as telomere shortening, proto-oncogene activation, oxidative stress, and cell-melting, which causes changes in cell state. Cellular aging involves many physiological phenomena, which can be beneficial to living organisms, such as inhibiting tumorigenesis, promoting wound healing, and embryonic development; it can also be harmful, such as the aging of organisms and the occurrence of pro-inflammatory aging-related diseases. However, the benefits and disadvantages of senescent cells generally depend on whether the senescent cells exist temporarily or persistently, the former being beneficial and the latter generally harmful. How does the anti-aging drug Senolytics fight aging? Eliminating aging cells is an anti-aging strategy that can be achieved through genetic engineering or taking anti-aging drugs. Dasatinib is an antihistamine traditionally used to treat cancer and leukemia, while quercetin is an antihistamine traditionally used to treat cancer and inflammation as a plant growth inhibitor. In 2015, Professor Deursen and others discovered that there are a series of drugs that can induce the death of aging cells in a targeted manner, but have little effect on non-aging cells. Therefore, they called these drugs Senolytics and are used to eliminate aging cells in the body. Because different types of Senolytics drugs have different mechanisms of action and remove different senescent cells, combined use often has better results. At present, Senolytics drugs reported in the literature include dasatinib, quercetin, navitoclax(ABT263), pipipermine base, fisedone, A1331852 and A1155463. Many drugs are undergoing clinical research and are expected to be put into use in the future. What are other anti-aging methods? As the average human life expectancy extends, cardiovascular diseases, cancer and neurodegenerative diseases that follow aging will increasingly affect the quality of life of the elderly. Therefore, scientists have studied various means to "anti-aging". Enhance the autophagy process in special types and periods of time through specific methods, directly eliminate aging cells, intermittent fasting, promote neurogenesis to reverse Alzheimer's disease, regular physical exercise, taking antioxidants and herbs, stem cell treatment, etc. What methods should I choose to prevent aging? Enhancing autophagy, using Senolytics to clear aging cells, infusing young people's plasma, and drugs to promote neurogenesis are all promising in anti-aging. However, most of these methods have been confirmed to be effective in animal experiments and still need clinical trials to evaluate long-term efficacy and side effects. Although Senolytics treatment has achieved certain clinical results, treatment cannot be performed frequently in order to reduce side effects. Stem cell therapy has been shown to promote the regeneration of aging brains and restore its function. However, clinical use requires evaluation of the safety and effectiveness of cells from different cell sources. Intermittent fasting, regular exercise, resveratrol and turmeric for the treatment of neurodegenerative diseases are preparing for large-scale clinical trials, and may also be a non-invasive method with the least side effects. We may really be able to determine our own life expectancy one day in the future, but until that day comes, a healthy lifestyle and good mental state are undoubtedly the secret to longevity now!