507 years ago today, July 3, 1518 (May 26, 1518, the 1518 lunar calendar), Ming Dynasty medical scientist Li Shizhen was born. Li Shizhen (1518-1593), also known as Dongbi, in his later years, called himself a Shanren from Binhu. He was born in Waxiangba (now Boshi Street) on Dongchang Street, Qizhou Town, Qichun County, Hubei Province. He was a famous medical scientist in the Ming Dynasty. He was later sentenced by Fengzheng Temple in the Chu Mansion and the Royal Hospital of Imperial Hospital. After his death, the Ming court issued the title of "Wenlin Lang". Since 1565, Li Shizhen has gone to Wudang Mountain, Lushan Mountain, Maoshan Mountain, Niushou Mountain, Huguang, Anhui, Henan, Hebei and other places to collect drug specimens and prescriptions. He has also served as his teacher by fishermen, woodcutters, farmers, coachmen, pharmacists, and snake catchers. He has referred to 925 books on medicine and other fields in the past dynasties to prove the present and study physics ", recorded tens of millions of words of reading notes, clarified many difficult problems. After 27 cold and summer periods, three changes were made. In the 18th year of Wanli of the Ming Dynasty (1590), the 1.92 million-word masterpiece "Compendium of Materia Medica" was completed. In addition, there was also research on pulse theory and the eight extraordinary meridians. He has written many books such as "Qisao of the Eight Paths of the Extraordinary Classics" and "Study of the Pulse of the Lake". The character studied medicine with his father, Li Shizhen. He was born on the 26th day of the fifth lunar month (July 3, 1518) in the 13th year of Zhengde of the Ming Dynasty, Wuzong, was born in the Wizhuang Dam of Dongchang Street, Qizhou Town, Qichun County, Hubei Province. His grandfather was a herbalist, and his father, Li Yanwen, was a famous doctor at the time and served as a case manager of the Imperial Hospital. At that time, folk doctors had a low status and lived a difficult life. His father did not want Li Shizhen to learn medicine again. When Li Shizhen was 14 years old, he followed his father to Huangzhou Prefecture to take an exam and returned home as a scholar. Li Shizhen was born in a family of doctors and loved medicine since he was a child. He was not keen on imperial examinations. Later, he went to Wuchang to take an exam three times, but failed, so he decided to abandon Confucian medicine and study medicine. At the age of 23, he studied medicine with his father, and his medical reputation is growing day by day. In the 30th year of Jiajing of Emperor Shizong of the Ming Dynasty (1551), when Li Shizhen was 38 years old, his medical reputation became famous for curing the son of King Zhu Houkun of Fushun. He was hired by Zhu Yingzhen, the King of Chu of Wuchang, as the "Chief of the Temple" of the Royal Palace, and was also in charge of the affairs of the good doctor's office. In the thirty-fifth year of Jiajing of the Ming Dynasty (1556), Li Shizhen was recommended to work in the Imperial Hospital. Awarded the position of "Imperial Hospital Judge". Three years later, he was recommended to Beijing Rentai Hospital for sentencing. After serving for one year, he resigned and returned to his hometown. There have been many debates in the historical circles regarding Li Shizhen's experience working in the Imperial Hospital. Some people believe that Li Shizhen once served as a judge of the Imperial Hospital (Zhengsixth grade), but others believe that he only served as a royal doctor (Zhengeighth grade). Regardless of his position, it is an undeniable fact that Li Shizhen was recommended to the DPRK. The working experience in the Imperial Hospital may have had a major impact on his life and laid the foundation for the compilation of the Compendium of Materia Medica. During this period, Li Shizhen was actively engaged in drug research, often visiting the pharmacies and imperial medicine warehouses of the Hospital of Traditional Chinese Medicine, carefully and carefully comparing and identifying medicinal materials from various places, collecting a large amount of information, and also had the opportunity to browse the wealth of classics collected by the royal family and the royal family, including "Collection of Essentials of Herbal Medicines". At the same time, he obtained a large amount of information about herbal medicine from the court about the people at that time, and saw many medicinal specimens that were difficult to see in ordinary times, broadening his horizons and enriching knowledge. Dongbi Hall Medicine Dongbi Hall was founded by Li Shizhen after returning to his hometown from Imperial Hospital in the 37th year of Jiajing of Emperor Shizong of the Ming Dynasty (1558). After resigning from his post and returning home, he sat in the hall to practice medicine and devoted himself to the investigation and research of drugs. During this period, he founded Dongbi Hall with his own word-Dongbi. During his decades of practicing medicine and reading classical medical books, Li Shizhen discovered that there were many mistakes in ancient herbal books and decided to recompile a herbal book. At the age of 35, he began to compile "Compendium of Materia Medica", based on "Zhenglei Materia Medica" and referred to more than 800 books. During this period, since the 44th year of Jiajing (1565), he left home many times to conduct inspections, and traveled all over Huguang, Jiangxi and Zhili. Many famous mountains and rivers have clarified many difficult problems. In the process of compiling the Compendium of Materia Medica, what gave Li Shizhen the most headache was that due to the mixed names of the drugs, they often couldn't figure out the shape and growth of the drugs. Although there were repeated explanations in the past, some authors did not conduct in-depth investigation and research, but copied from book to book. Therefore, the more explanations, the more confused they became, and the more contradictions appeared, making people confused. For example, the drug Polygala. Tao Hongjing, a famous medical scientist in the Northern and Southern Dynasties, said that it was grass, like Ephedra, but it was green in color and had white flowers. However, Ma Zhi in the Song Dynasty thought it looked like Daqing and blamed Tao Hongjing for not knowing Polygala at all. Another example is the medicine of Cishi. Some say it looks like yam japonica, some say it looks like Chinese lily, and some say it looks like strumpet. The explanations are very inconsistent. Under the inspiration of his father, Li Shizhen realized that "reading thousands of books" is necessary, but "traveling thousands of miles" is even more indispensable. Therefore, he not only "collected hundreds of scholars", but also "interviewed all directions" to conduct in-depth investigations. Agkistrodon snake is a white snake produced in Qizhou. This medicine has the functions of treating wind arthralgia, twitching, and mangy. Li Shizhen had long studied it, but at first only observed it from snake dealers. Insiders reminded him that it was caught from the mountains of Xingguo Prefecture in Jiangnan (now Yangxin County) and was not a real Agkistrodon. In order to find the real Agkistrodon snake, he consulted a snake catcher, who told him that the tip of the Agkistrodon snake's teeth was highly toxic. If a person was bitten, his limbs had to be amputated immediately, otherwise he would die of poisoning. It has special effects on various diseases, so it is very valuable. State officials forced the masses to risk their lives to capture them in order to pay tribute to the emperor. Qizhou is so big, but in fact, only Longfeng Mountain in the north of the city can have real Agkistrodon snakes. Li Shizhen wanted to observe the snake with his own eyes, so he asked the snake catcher to take him up Longfeng Mountain. There is a Suānní cave in Longfeng Mountain. The cave is surrounded by strange rocks and bushes, with heather vines winding around the bushes. Agkistrodon likes to eat the leaves and leaves of heather vines. With the help of the snake-catching snake, it finally saw the Agkistrodon snake with its own eyes and saw the whole process of catching and making snakes. When "Compendium of Materia Medica" wrote about the agaricus, it was concise and accurate. When Li Shizhen understood drugs, he was not satisfied with conducting a cursory investigation. Instead, he "looked at them one by one to get the truth","listed the various products and looked at them repeatedly", and compared and checked the real objects. In this way, many specious and ambiguous drugs were clarified. Dace carp, or pangolin, is a commonly used traditional Chinese medicine. Tao Hongjing said that it can be amphibious on both land and land. It climbs up the rock during the day, opens its scales, and acts dead. It lures ants into the armor, then closes its scales, dives into the water, and then opens its armor to allow the ants to emerge, and then eats them. In order to understand whether Tao Hongjing's statement was correct, Li Shizhen personally went up the mountain to observe. With the help of a woodcutter and hunter, he caught a pangolin. About a liter of ants were cut out from its stomach, confirming that the pangolin animal was right. However, from observation, he found that when pangolin ate ants, it scratched open the ant's nest and licked it, rather than luring the ants into the armor and swallowing them in the water. Li Shizhen affirmed Tao Hongjing's right side and corrected his mistakes. After 27 years of long-term efforts, the first draft of "Compendium of Materia Medica" was completed in the sixth year of Wanli of Shenzong of the Ming Dynasty (1578) at the age of 61. It was revised three times in 10 years, totaling 40 years. He died in the 22nd year of Wanli (1593 AD). In the 25th year of Wanli (1596), three years after Li Shizhen's death, Compendium of Materia Medica was officially published in Jinling (present-day Nanjing).