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October 28, 2016 The world's first gene editing technology for the treatment of lung cancer
On October 28, 2016 (September 28, 2016 in the lunar calendar), the first patient with advanced lung cancer received gene editing treatment in West China Hospital. According to foreign media, Chinese scientists have used the revolutionary CRISPR-Cas9 gene editing technology in the human body, which is the first in the world. In mid-August 2016, West China Hospital was recruiting ten subjects, and the conditions required for the patients were: the disease was metastatic non-small cell lung cancer, and there was no progress after standard treatment such as chemotherapy, radiotherapy or targeted therapy. On November 15, the authoritative "Nature" magazine revealed that the first lung cancer patient had received cell reinfusion in West China Hospital on October 28, 2016. Professor Lu said that the treatment of the first patient was basically smooth and would receive a second cell reinfusion. Due to patient privacy, the details will not be released yet, and there will be about two to four cell reinfusions. Huaxi Hospital's experiment mainly uses gene editing technology to knock out the "PD-1" in the specific T cells in the tissues of lung cancer patients, and then infuse them back into the patient's body to kill those cancer cells. The person in charge of this project, Professor Lu Yu of Huaxi Hospital, is to find specific T cells from the inside of the enemy (cancer cells), "brainwash" them in vitro through gene editing technology, and then transfuse them into the human body. Because the T cells after "brainwashing" are more familiar with the characteristics of cancer cells, they will be more effective in attacking cancer cells and easier to kill cancer cells. The so-called fortress is often broken from the inside. What cannot be ignored is that after the "brainwashed" cells are injected back into the human body, will they attack the normal tissues and cells in the human body, resulting in serious side effects? This question has not yet been given relevant data by the experimental group, and there is no answer for the time being. We still need to wait for the results of clinical trials. Professor Lu's experiment, both in terms of scientific significance and in the history of cancer cure, will be the innovation of gene editing technology on a global scale - the first application of gene editing (CRISPR-Cas9) technology to the human body. And Han Chunyu's NgAgo technology gene editing technology of Hebei University of Science and Technology, which has caused a stir in the Chinese scientific community this year, is a simpler technology than CRISPR-Cas9, but it has been widely questioned because the experiment cannot be repeated. It is also necessary to understand that this method of "brainwashing" anti-cancer through gene editing technology is essentially immunotherapy, and there is no clinical data in the world to prove that immune cell therapy can effectively treat lung cancer. In addition, according to scientific ethics and legal regulations, experimental new drugs and new technologies are completely free.


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