On November 23, 2006 (October 3, 2006 in the lunar calendar), Chinese biochemist Zou Chenglu passed away. Zou Chenglu (1923-2006) Zou Chenglu, a native of Wuxi County, Jiangsu Province, graduated from Nankai University in Chongqing in 1941, from the Department of Chemistry of Southwest United University in 1945, and from Cambridge University in 1951. After returning to China in 1951, he successively served as an associate researcher, researcher, and director of the Institute of Biochemistry and the Institute of Biophysics of the Chinese Academy of Sciences. For his contributions to the artificial synthesis of insulin, protein and enzymes, he has won the Third World Academy of Sciences Award, the Chen Ka Kee Prize for Life Sciences, and the National Natural Science Award of the National Academy of Natural Sciences and the Chinese Academy of Sciences for Natural Science many times. His contributions to the development of contemporary biochemistry have been recorded in the annals of history. Since 1978, he has served as a member of the Fifth to Eighth Session of the National Committee of the Chinese People's Political Consultative Conference and a member of the Eighth Standing Committee. Now he is an academician of the Chinese Academy of Sciences, an academician of the Third World Academy of Sciences, and an honorary member of the American Society of Biochemistry and Molecular Biology. He has served as a member of the Presidium of the Chinese Academy of Sciences, the Director of the Department of Biology, a member of the National Natural Science Foundation of China, and a member of the Academic Degrees Committee of the State Council. Over the years, he has served as the editorial board of some important scientific journals at home and abroad, including the deputy editor of the Chinese Science and Science Bulletin AnalyticalBiochemistry and the editorial board of BiochimicaetBiophysicaActa, and the advisory editorial board of Biochemistry and From 1986 to 1990, he served as a Fogarty Fellow of the National Health Research Institute. Academician Zou Chenglu discovered the difference in the properties of purified cytochrome C when bound to mitochondria; the study of respiratory chain enzymes laid the foundation for the study of enzymes in our country; responsible for the disassembly of A and B chains in the artificial synthesis of insulin, and determined the synthesis route; The quantitative relationship formula and mapping method of chemical modification and activity loss of protein essential groups are called "Zou's formula" and mapping method; The new method of irreversible inhibition kinetics theory of enzyme action and the determination of reaction rate constants has been widely used in the world; Regarding the three-phase reduction of cytochrome b, the insulin A and B chains themselves contain the necessary information to form a complete molecule. Under weak denaturation conditions, the loss of enzyme activity precedes the conformational change of the whole molecule, so the enzyme activity site It has high flexibility and is necessary for enzyme activity, etc., all of which are pioneering work. In 1980, he was elected as an academician of the Chinese Academy of Sciences (member of the Faculty). Published more than 200 research papers in important journals at home and abroad. Due to his contributions in the field of biochemistry, he won the Biology Prize of the Third World Academy of Sciences in 1992. Synthetic insulin, chemical modification of protein essential groups and quantitative relationship between enzyme activity loss, won the second and third national natural science first prizes respectively, the latter also won the 1989 Chen Jiageng Award. The formation of new fluorophores at the active site of glyceraldehyde-3-phosphate dehydrogenase, the flexibility of the active site of the enzyme, and the kinetics of irreversible inhibition of enzyme action have won the first prize of scientific and technological progress or natural science of the Chinese Academy of Sciences three times. In addition, he has won the second and third prizes of the National and Chinese Academy of Sciences in Natural Sciences for many times. His contributions to science have been recorded in the annals of history. At the invitation of foreign friends, his autobiography has been published in the Comprehensive Biochemistry comprehensiveBiochemistry, Volume 37, History of Biochemistry. Comment: Defender of Scientific Truth in China's Biochemical Revolution