On March 17, 2016 (February 9, 2016 in the lunar calendar), Ponzi's mother and daughter illegally operated vaccine cases. Shanxi Vaccine Incident On March 17, 2010, according to relevant media reports, nearly 100 children in Shanxi died, were disabled or caused various sequelae due to unknown causes. Parents are heartbroken, seek treatment everywhere, and bear a heavy burden. Where is the source of the disease that caused such a tragedy? Persistent parents of children have questioned: "How can they get JE after receiving the JE vaccine?" "Acute disseminated encephalomyelitis is not caused by vaccination?" Vaccination is illegal, or is the "high temperature exposure" vaccine ineffective?... The target is the vaccine used to protect people's lives and health! In the past few days, with the disclosure of a five-year-old case of illegal vaccine business affecting 18 provinces, the public opinion circle has become lively again. Today, an old article titled "The Death of Vaccines" is swiping the screen at Moments, fiddling the public's already tense nerves. The voices of questioning and refuting rumors are one after another, and both sides of public opinion are not afraid to use the worst malice to speculate about each other. In the face of major public events, fear and distrust will always appear. Because of this, we should stay sober and rational, and recognize the essence of the incident. In the case of the illegal operation of vaccines by the Pang mother and daughter, the vaccines they operate are all legal vaccines produced by regular manufacturers. The essence of the problem lies in the distribution link rather than the production link. According to the "Regulations on the Administration of Vaccine Circulation and Vaccination" promulgated by our country in 2005, vaccines are divided into two categories. The first category is vaccines that the government provides free of charge to citizens, and citizens have corresponding obligations to vaccinate; the second category is vaccines that citizens vaccinate at their own expense and voluntarily. Correspondingly, the regulations also have different regulations on the circulation of the two vaccines. According to the regulations, the first type of vaccine is that the procurement department directly signs a government procurement contract with vaccine manufacturers or wholesale enterprises. The main body of the contract is the government department. There is a clear invite tenders process, and the supervision is relatively strict. Moreover, manufacturers and wholesale enterprises are required to provide them directly to disease control agencies, and they cannot be distributed or resold, and there is no profit margin. Therefore, illegal vaccines cannot and will not take advantage of such vaccines. The second type of vaccine is directly sold by manufacturers or vaccine wholesale enterprises to disease control agencies, vaccination units, and wholesale enterprises. The sources of vaccines are diverse, so there is a dead end of supervision. Coupled with the fact that the second type of vaccine can be profitable, it has led to the circulation of illegal vaccines. In the case of the illegal vaccine seized by the police in a warehouse in Tianqiao, Pang used his identity as a hospital pharmacist to sell the tail goods of vaccines that should have been destroyed in the hospital to other drug companies, reflecting the lack of supervision by the hospital and the drug regulatory department. As a mother and daughter of Pang, many pharmaceutical companies that went offline did not purchase vaccines from formal channels as wholesalers, and they also had an unshirkable responsibility. From the bottom up, the grass-roots epidemic prevention stations and hospitals need to ask the wholesale company for the certificate of passing the inspection or review and approval of each batch issued by the drug inspection agency. The origin of these illegal vaccines is unknown, so they naturally cannot provide corresponding certificates. When the vaccination unit purchases them, it is natural that they take a fancy to the cheap bright spot of this batch of vaccines in order to obtain more benefits during the vaccination process. It can be seen from this sales chain that the lack of vaccine traceability mechanism and the imperfect supervision have led to market confusion in the procurement and distribution process of the second type of vaccine. The huge profit cake has made the distribution agencies at all levels adopt a selectively blind attitude towards the regulations. In the exchanges between Uncle Island and some preventive medicine practitioners, many people mentioned a term - the Vaccine Temperature Detection Card (VVM), and many media reports have also mentioned the self-testing technology of this vaccine. Vaccines cannot completely avoid leaving the cold chain during transportation and storage, and it is impossible to judge whether the vaccine has deteriorated with the naked eye. If the vaccine has deteriorated due to heat, this test strip can be reflected by the color change, to a certain extent, to avoid the deterioration of the vaccine being vaccinated. However, technical guarantees are still not a cure for the root cause. Even if the vaccine is safe and effective, the chaotic market is still there. To solve these various crux, we still need to rely on a long-term and effective regulatory system with clear powers and responsibilities. Although the matter of supervision has been said thousands of times, it is still necessary to mention it again at this time. Many people are worried that the biggest adverse consequences of this illegal vaccine business incident may not be the deterioration of the vaccine itself, but the public's resistance and distrust of the vaccination work. The strongest reaction among Moments is the parents of those children who are still young. This incident has made them hesitant, and even some people have begun to question our country's neonatal vaccination system. First of all, as mentioned before, the illegal vaccines exposed this time are all on the second type of vaccine. It is stipulated that the vaccines such as BCG vaccine, DPT vaccine, and polio sugar pills for vaccination are relatively formal and strict from production to procurement. The most important thing is that vaccines are an effective way to control and eliminate diseases since human beings entered modern times. According to the Chinese Center for Disease Control, vaccination can avoid 2 million to 3 million deaths every year. The smallpox virus we are familiar with has been with human beings throughout ancient history, and hundreds of millions of people died from the smallpox virus. The historical book "Bacteria, Guns and Iron" describes the civilization disaster that caused the death of the Native American people by smallpox carried by European colonists. The appearance of the cowpox vaccine has alleviated the spread of smallpox. Since the 20th century, people have continuously modified vaccines, so that we finally eliminated the smallpox disease in the 1980s. China has been making disdainful efforts to popularize vaccines. In 2000, China achieved the goal of being polio-free, and polio became a historical word. In 2012, the incidence of measles, whooping cough, meningitis, and Japanese encephalitis in the country dropped by more than 99% compared with 1978, and neonatal tetanus has also been eradicated. The World Health Organization says that compared with people's doubts, China's vaccination is not only not widespread, but there are loopholes in some aspects. From the perspective of the vaccination population, China's migrant children belong to the missing group in terms of vaccination. From the perspective of the type of vaccine, China's heterogeneous vaccines need to add three vaccines such as Haemophilus B vaccine to meet the world standard. To put it bluntly, vaccination is both a right and an obligation. Vaccination is a rigid demand, which is full of games and entanglements between public interests, personal interests, and capital interests. When maximizing public rights and interests, there will naturally be people who would rather believe it than not, and want to stay out of it. And when capital intervenes in it with a greedy attitude, it will swallow them all. Balancing public welfare and private interests, and supervising the ambition of capital, vaccination should not be a problem. The most terrifying thing about the truth is that the truth is still unknown. This makes all speculation have an irrefutable basis, and also makes all excessive defense seem full of reasons. Premier Li Keqiang has instructed that the vaccine safety incident has aroused great concern in society and exposed many loopholes in supervision. The Food and Drug Administration, the Health and Family Planning Commission, and the Ministry of Public Security must effectively strengthen coordination and cooperation, thoroughly investigate the flow and use of "problematic vaccines", respond to social concerns in a timely manner, crack down on illegal and criminal acts in accordance with the law, and seriously hold relevant negligence accountable and will not tolerate it. To summarize the key words: many loopholes, the Food and Drug Administration, the Health and Family Planning Commission, the Ministry of Public Security, social concerns, and negligence. And what we ultimately want is nothing more than truth, truth and truth. No matter whether it is a regulatory loophole or a chain of interests, whether it is an accident or a systemic problem, in the face of the real concerns of the public, only an open and transparent process and convincing results are the best response, rather than allowing rumors and refutations to exhaust the public's nervous nerves.